• ILikeBoobies@lemmy.ca
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    5 hours ago

    I was unaware that an X chromosome could mutate into a Y and vice versa over the course of a lifetime. Do we know what causes that?

    • Sibshops@lemm.ee
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      5 hours ago

      They are not saying that the X chromosome mutates to Y, but rather saying that XY doesn’t define the sex. For example, some people with XY are born with female genitalia and look female their whole lives. Sometimes they don’t find out they are XY until trying to have kids and are unable to. It isn’t like the X changes to Y over time. That isn’t possible.

        • Sibshops@lemm.ee
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          5 hours ago

          I think you may have misread. The PHD isn’t saying that XY becomes XX, they are saying, genetically, a person carrying XY can be a cis woman. Biologically, XY doesn’t determine the sex.

          • Tamei@lemm.ee
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            3 hours ago

            I honestly don’t understand. What does define the sex biologically? The genitalia, then? I always understood positions like William’s like “XY is the biologically male sex by definition, if the human develops female genitalia and feels like a woman they were biologically speaking still intended to be a man.” I don’t understand what else there could be on an elemental level to biologically determine the sex.

            • Sausa@beehaw.org
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              2 hours ago

              There’s no one thing that defines sex, that’s what makes it so complicated. What is often thought of as “biological sex” are two clustered sets of checkboxes (e.g chromosomes, genitalia, secondary sex characteristics, primary sex hormone), but people often have a mixture from both lists. Here’s an interesting nature article on it https://www.nature.com/articles/518288a

            • JustAnotherRando@lemmy.world
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              2 hours ago

              To preface: this is from a previous bout of hyper focus curiosity (i.e. I am not an expert). But the human genome is significantly more complex than “XX chromosome means biological female”. Other genomic markers can trigger that don’t align with the typical, which can result in male reproductive organs on a person with XX chromosome and vice versa. XX and XY are also not the only options. There are three, four, and even five somal groupings (e.g. XXY, XYY, XXX - note that to my understanding, you can’t have all Y chromosomes even in these outliers). If anyone has further information or any corrections for me, I’d welcome them - I’m going off of memory from a couple of years ago and it’s not directly relevant to me (i.e. I am cis-male with no known chromosomal abnormalities)

        • Uruanna@lemmy.world
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          5 hours ago

          It’s weird how your first thought is “the PhD is wrong” and not “I must have misunderstood something” .

          • ILikeBoobies@lemmy.ca
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            4 hours ago

            “I must have misunderstood something” .

            There was a reason I made that comment

            Though I disagree with the conservative genitalia = gender ideology