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Cake day: June 11th, 2023

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  • dgkf@lemmy.mltoComic Strips@lemmy.worldEpigenetics
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    6 days ago

    Although the immediate processing of food might occur in major digestive organs, the effect of increased or decreased nutrient availability will be felt throughout the body. One primary effect of starvation is the breaking down of cells (autophagy) in order to reuse their components for more necessary bodily functions - like the atrophying of muscles.

    Naturally, your germ line cells are one of your core bodily functions, so the nutrients will necessarily need to make their way there.

    One recent paper[1] hypothesized that the byproducts of this cellular breakdown can cause cells to bundle up DNA that encodes some genes, rendering them less accessible and therefore less active. This can even be passed trans-generationally (presumably by altering the tight storage of specific genes in the germ line cells).

    Broadly this mechanism is called epigenetics, where specific histone protein modifications cause regions of DNA to coil up tightly, making it far less likely to be expressed, or unwind and become far more active. It’s a very neat mechanism by which many characteristics can become generational despite not having a clear genetic component.

    [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC10244352/


  • dgkf@lemmy.mltoGaming@lemmy.worldThe Mario Party Stigmata
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    1 month ago

    I fell victim to this one on authentic “retro” N64 hardware, which has a hard plastic analog stick. Got an enormous blister right on the palm of my hand trying to win this tug of war. Of course, my young brain was able to hyperfocus on the game and completely tuned out any sense of pain in my hand. It was quite gruesome when I finally beat it and realized my hand was torn to shreds. I was at my neighbors place and I remember how shocked their mom was. She applied some cream that I think was meant for severe burns.

    Nintendo would later run a campaign where they’d send you fingerless gloves for free to try to do some damage control on all the negative press when reports started popping up.


  • If you’re just looking to get started with 3d modeling, it’s hard to beat Blender. At the cost of free, it’s by far the most affordable way to dip your toes in some modeling tools.

    For many workflows it’s world class. If you plan to do more organic forms or don’t need technical precision, then it’s very competitive or preferable to paid software.

    You might find it lacking if you plan to do parametric or technical CAD-style modeling. Even then, I think Blender can be a low cost way to learn what you want in your software before investing in more specialized software. You’ll learn enough of the modeling basics to more fluently navigate what other software provides.




  • If it helps, think of the water first like a perfect mirror. If it’s a perfectly flat mirror then it would look like there’s another duck upside down below this duck. If you want to be extra precise, it’s mirrored across the plane where the duck meets the water.

    But water isn’t usually perfectly flat mirror, and here you have little nods to there being ripples or waves. The choppier the wave, the less it reflects, so you’ll often see people break up the mirrored reflection at the choppiest parts of the wave. Similarly, waves aren’t flat, depending on the part of the wave/ripple you’re at, you’d be reflecting higher or lower as though the mirror is tilted to the angle of the surface.

    The last tricky part is that most surfaces are more reflective at a glancing angle than head on, so often reflections are stronger further in the distance and closer up you’ll just be looking down into the water. On a more technical note, you can look up the index of refraction to learn more about this phenomenon.

    To tie it all together, this is why those long shots of sunsets have a sun reflection that is really long (much longer than the size of the sun in the distance) - because it’s at a distance it’s a strong reflection and because all the waves are reflecting at different angles you’re getting all the glancing reflections of the sun on the top of each wave. It typically being dark at sunset also means the bright sun reflection blooms to make it look brighter and larger than just the tip of the wave.

    Conversely, in water sports like wakeboarding, you might not see much of a reflection at all because all the water is choppy and non-reflective.

    Looking down into a pond, you might not see a reflection either because the angle is too steep to reflect.

    In short, yes, in this case the reflection should probably be roughly the same size.


  • Permissive licenses permit a broader range of use compared to “copyleft” licenses.

    “copyleft” here just being a cute way of being the opposite of copyright - instead of disallowing others from what they can do with “copyrighted” code, “copyleft” requires that they (upon request) share modifications to your code.

    Permissive takes away this requirement to share your modifications. “copyleft” is considered more free and open source (FOSS), permissive is more business friendly.



  • I don’t want to detract anything from this tram photo, but I also know that with all the content floating around in the internet these days it’s easy to build unrealistic tram expectations.

    I think this is two trams, each on their own line. Notice how the roof line steps down and the window reflections seem to change halfway through. I think they’re just very conveniently aligned for the photo to make it look like one double length tram.



  • Which part sounds off to you? This looks like a very reasonable paper hoping to distill traditional medicine into viable research paths, and does it using a pretty interesting model of compounds and effects.

    If all you see is jibber jabber, maybe you should just default to trusting the experts on this one? Like, it’s not in an obscure journal - it’s a highly regarded peer reviewed journal. The authors aren’t random, they’re researchers at some of the best universities in the world (Nanjing University ranks #7 on the Nature Index).

    The abstract is about as plain-speaking as it gets in the world of cutting edge research. You can probably look up the handful of domain-specific terminology and have a good grasp at what the research is about.





  • I don’t know anything about being an electrician - commercial or otherwise, so I’m curious to hear your side.

    When all those people go to working remote, it’s not like they’re no longer in need of electricity. Presumably their home demand is higher and we might even see people adding new office spaces to adapt their home. Maybe the public grid needs to change to support it? Won’t this mean that there will just be a different type of demand for electricians?

    Are there reasons this would be less attractive to electricians? Pay, job security, or something else?



  • For anyone who’s curious, this is the state of discussing this feature: https://github.com/helix-editor/helix/discussions/8572

    I’m not an authority on the helix ethos, but I’ve contributed a bit and hung around long enough to have a good read on their stance on most topics. The project is still young and managing the growing pains of getting a lot of traction relatively early. I think the devs value keeping the maintenance footprint small to keep the project sustainable.

    The philosophy of helix’s design is to be a more convenient kakoune, not necessarily a vim. vim is much more widely known, so that analogy springs up more often, but this idea of using piping out to an external command for most operations comes from kakoune.

    For features that would introduce significant maintenance overhead, may jeopardize the performance of a more common workflow or where the design goals are still maturing, the team tends to push such suggestions toward being developed as plugins when that system is added. I get the impression that they see the value of this workflow, but would prefer to see it battle tested as a plugin first.


  • I’ve been there, but over the years I’ve gotten better at avoiding being in this situation.

    If you are implementing something for yourself, and merging it back upstream is just a bonus, then by all means jump straight to implementing.

    However, it’s emotionally draining to implement something and arrive at something you’re proud of only to have it ignored. So do that legwork upfront. File a feature request, open a discussion, join their dev chat - whatever it is, make sure what you want to do is valued and will be welcomed into the project before you start on it. They might even nudge you in a direction that you hadn’t considered before you started.

    Be a responsible dev and communicate before you do the work.


  • Thanks for sharing! Really interesting history in this article. It’s scary to think what a world would look like if Sun didn’t sue Microsoft into oblivion and put an end to this strategy.

    We could be living in a world where Windows is the dominant desktop OS instead of our beloved Solaris.

    To be serious, though, being sued/forced to settle isn’t an indicator that the strategy hasn’t worked. In fact, as is evident by the continued doubling down on the strategy by Microsoft and the unfettered execution of this strategy with Chrome, it’s clear that the value far outweighs the cost of the occasional settlement. The only real deterrent is antitrust regulation and that has been just about entirely defanged. These concerns are especially pertinent for something like Lemmy where there’s no central entity to soak the legal fees to go to court.