That meme is about sexism not self defense. You can argue pro or con if someone breaks in, possibly armed, people might be scared and fear being raped etc and have a right to defend themselves. The problem:

While you’re arguing you’re ignoring the sexism inherent in the depiction of the “annoying AOC women limbrol” on top vs the “grinning cool chad” on the bottom panel.

It’s like the perfect meme complex to deliver it’s fascist message hiding below a debatable shit-message. Both sides will repost this and debate and thus the sexist underlying message spreads.